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Databases

Researchers at UNC have extensive experience conducting epidemiologic research with a wide variety of population-level clinical and healthcare utilization databases including:

  • Medicare Parts A, B, and D (possibility to link with UNC clinical data)
  • Merative Marketscan Research Databases
  • Surveillance, Epidemiology and End Results (SEER)-Medicare
  • United States Renal Data System (USRDS), linked with DaVita EMR data
  • National COVID Cohort Collaborative (N3C)
  • National Health and Aging Trends Study (NHATS) – Medicare Linked Data
  • North Carolina Medicaid, project-specific linkage to UNC electronic medical record (EMR) data
  • Carolina Data Warehouse for Health (CDW-H) EMR (possibility to link with Medicare)
  • Atherosclerosis Risk in Communities Study (ARIC), Women’s Health Initiative Study (WHI), both linked with Medicare data
  • Blue Cross Blue Shield of NC (2006-2017) data, project-specific linkage to UNC EMR data
  • MidSouth Clinical Data Research Network (CDRN) with EMR data from UNC, Duke, Vanderbilt, MUSC
  • UNC is a PCORnet site
  • UNC Lineberger Center – Cancer Information & Population Health Resource (CIPHR)

 

UNC provides excellent infrastructure for large, multicenter studies. Prime examples include the North Carolina Translational and Clinical Sciences Institute (NC TraCS), funded through the National Institutes of Health (NIH) Clinical and Translational Science Awards, and UNC’s Collaborative Studies Coordinating Center, part of the public health school’s biostatistics department which was established in 1971 as the second coordinating center to be funded by the NIH.

 

Research Tools

 

UNC Pharmacoepidemiology Publications

To obtain a list of all publications from UNC PE faculty listed on PubMed click here.

Please click on the words in the table below to link to a current PubMed bibliography of the UNC PE faculty publications pertaining to specific data sources, therapeutic areas, study objectives, and methods.

Data Sources

Therapeutic Areas

Study Objectives

Methods

EMR

Linkage

MarketScan

Medicaid

Medicare

Methods

NC Commercial Claims

Prospective Cohort

SEER Medicare

Simulation

Trial Data

Validation

Cancer

CVD

Diabetes

Infectious disease

Kidney disease

Mental health

Opioids

Pelvic floor disorders

Pregnancy

Vaccines

 

Adherence

Effectiveness

Risk factors

Safety

Treatment patterns

Utilization

Validation

 

Doubly

Instrumental variable

Maximum likelihood

Propensity Scores

Self-controlled

 

 

 

Recent Publications

Names in bold are current students on the pharmacoepidemiology program

A list of publications, both students and faculty in the program for the 2022-2023 academic year can be found here.

 

Eiffert SR, Stürmer T, Thorpe CT, Traub R, Raman SR, Pate V, Kinlaw AC. Vaccine patterns among patients diagnosed with Guillain-Barré Syndrome and matched counterparts in a Medicare supplemental population, 2000-2020. Vaccine. 2023 Aug 10:S0264-410X(23)00947-7. doi: 10.1016/j.vaccine.2023.08.014. Epub ahead of print. PMID: 37573203.
 
Kilicoglu H, Jiang L, Hoang L, Mayo-Wilson E, Vinkers CH, Otte WM. Methodology reporting improved over time in 176,469 randomized controlled trials. J Clin Epidemiol. 2023 Aug 8:S0895-4356(23)00202-0. doi: 10.1016/j.jclinepi.2023.08.004. Epub ahead of print. PMID: 37562729.
Lewis JD, Parlett LE, Jonsson-Funk ML, Brensinger C, Pate V, Wu Q, Dawwas GK, Weiss A, Constant BD, McCauley M, Haynes K, Yang JY, Schaubel DE, Hurtado-Lorenzo A, Kappelman MD. Incidence, Prevalence and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States. Gastroenterology. 2023 Jul 15:S0016-5085(23)04776-5. doi: 10.1053/j.gastro.2023.07.003. Epub ahead of print. PMID: 37481117.
Kahrs JC, Van Wickle K, Delahanty MT, Wood ME. Perinatal Outcomes After Bariatric Surgery Compared With a Matched Control Group. Obstet Gynecol. 2023 Aug 1;142(2):429. doi: 10.1097/AOG.0000000000005273. PMID: 37473417.
Robinson WR, Mathias JG, Wood ME, Anderson LG, Howard AG, Carey ET, Nicholson WK, Carey TS, Myers ER, Stürmer T, Doll KM. Ethnoracial Differences in Premenopausal Hysterectomy: The Role of Symptom Severity. Obstet Gynecol. 2023 Aug 1;142(2):350-359. doi: 10.1097/AOG.0000000000005225. Epub 2023 Jul 5. PMID: 37473411; PMCID: PMC10351903.
Winterstein AG, Ehrenstein V, Brown JS, Stürmer T, Smith MY. A Road Map for Peer Review of Real-World Evidence Studies on Safety and Effectiveness of Treatments. Diabetes Care. 2023 Aug 1;46(8):1448-1454. doi: 10.2337/dc22-2037. PMID: 37471605; PMCID: PMC10369122.
Duchesneau ED, Shmuel S, Faurot KR, Park J, Musty A, Pate V, Kinlaw AC, Stürmer T, Yang YC, Funk MJ, Lund JL. Translation of a claims-based frailty index from International Classification of Diseases 9th Revision to 10th Revision. Am J Epidemiol. 2023 Jul 11:kwad151. doi: 10.1093/aje/kwad151. Epub ahead of print. PMID: 37431778.
 
Latour CD, McGrath LJ, Clouser M, Nielson C, Yu Y, Balasubramanian A, Breskin A, Brookhart MA. Controlling for Differential Regression-To-The-Mean via Propensity Scores: A Simulation Study. Clin Epidemiol. 2023 Jun 1;15:661-670. doi: 10.2147/CLEP.S406552. PMID: 37284516
 
Keshwani S, Smith SM, Brown J, Lo-Ciganic WH, Yang S, Smolinski NE, Hincapie-Castillo JM. Trends in Prescribing of Non-steroidal Anti-inflammatory Medications in the US Ambulatory Care Setting From 2006 to 2016. J Pain. 2023 Jun 15:S1526-5900(23)00442-X. doi: 10.1016/j.jpain.2023.06.008. Epub ahead of print. PMID: 37330160.